Saturday, May. 1, 2021
Did the CDC change the laboratory standard for determining a positive coronavirus test result?
Claims that the Centers for Disease Control has changed its coronavirus testing standards are based erroneously on instructions for labs submitting coronavirus specimens for sequencing in further research. CDC standards for determining whether someone has been infected by the virus haven’t changed.
The CDC is asking labs to screen for specimens with relatively high “viral loads” in order to help study so-called “breakthrough” COVID-19 cases among fully vaccinated people. To determine the load, scientists look at a figure called cycle threshold. Generally, a lower figure indicates a higher viral load, facilitating more accurate and complete examination of the virus.
The relationship between a specific threshold and symptoms and progression of COVID-19 disease are not yet well understood. Higher thresholds continue to be used in general testing for the presence of the virus.
This fact brief is responsive to conversations such as this one.
Sources
- US Centers for Disease Control COVID-19 vaccine breakthrough case investigation
- US Food and Drug Administration CDC Coronavirus test instructions (see p. 36)
- US Centers for Disease Control FAQs for labs—Interpreting results of diagnostic tests
- Science One number could help reveal how infectious a COVID-19 patient is. Should test results include it?
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Fact briefs are bite-sized, well-sourced explanations that offer clear "yes" or "no" answers to questions, confusions, and unsupported claims circulating online. They rely on publicly available data and documents, often from the original source. Fact briefs are written and published by Gigafact contributor publications.
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