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Please note!
This fact brief was originally published as an experiment to test the concepts behind fact briefs.
Readers should be aware that while there is still a lot of useful information in fact briefs like this one, not all of them reflect Gigafact's current methods and standards for fact briefs. If you come across any that you feel are out of date, don't hesitate to contact us at support@gigafact.org.

Is there evidence that progesterone may prevent some miscarriages?

By Seth Smalley
YES

Progestogens, including natural progesterone, may slightly decrease the chance of miscarriage in at-risk women. Progesterone thickens the uterine lining in preparation for pregnancy and helps nurture the fetus.

In a 2017 meta-analysis of 13 clinical trials involving 2,556 women who experienced recurring miscarriages, progestogen was found to lower the chance of miscarriage from 27.5% to 20.1%, though the findings were based on "evidence of only moderate quality." A 2013 review of previous studies found "no evidence to support the routine use of progestogens" for treating the threat of miscarriage. It acknowledges studies that found that it might be a successful therapy for women who miscarry frequently, but criticized those studies' methods.

This fact brief is responsive to conversations such as this one.
ABOUT THE CONTRIBUTOR
Between 2020 and 2022, under close editorial supervision, Gigafact contracted a group of freelance writers and editors to test the concepts for fact briefs and provide inputs to our software development process. We call this effort Gigafact Foundry. Over the course of these two years, Gigafact Foundry writers published over 1500 fact briefs in response to claims they found online. Their important work forms the basis of Gigafact formats and editorial guidelines, and is available to the public on Gigafact.org. Readers should be aware that while there is still a lot of relevant information to be found, not all fact briefs produced by Gigafact Foundry reflect Gigafact's current methods and standards for fact briefs. If you come across any that you feel are out of date and need to be looked at with fresh eyes, don't hesitate to contact us at support@gigafact.org.
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